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Treatment of adductor spasticity with BTX-A in children with CP: a randomized, double-blind, placebo-controlled study

✍ Scribed by Volker Mall; Andrea Siebel; Christoph Bertram; Ulrich Hafkemeyer; Jörg Wissel; Steffen Berweck; Fritz Haverkamp; Günter Nass; Leo Döderlein; Nico Breitbach-Faller; Wilhelm Schulte-Mattler; Rudolf Korinthenberg; Florian Heinen

Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 105 KB
Volume: 48
Category: Article
ISSN: 0012-1622
DOI: 10.1017/s0012162206000041

No coin nor oath required. For personal study only.

✦ Synopsis

Adductor spasticity in children with cerebral palsy (CP) impairs motor function and development. In a placebo‐controlled, double‐blind, randomized multicentre study, we evaluated the effects of botulinum toxin A(BTX‐A) in 61 children (37 males, 24 females; mean age 6 years 1 month [SD 3y 1mo]) with CP (leg‐dominated tetraparesis, n=39; tetraparesis, n=22; GMFCS level I, n=3; II, n=6; III, n=17; IV, n=29; V, n=6). Four weeks after treatment, a significant superiority of BTX‐A was observed in the primary outcome measure (knee‐knee distance ‘fast catch’, p=0.002), the Ash worth scale (p=0.001), and the Goal Attainment Scale (p=0.037).

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