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Treatment Algorithms in Metastatic Renal Cell Carcinoma, Including the Potential Role of the Novel Oral Mammalian Target of Rapamycin Inhibitor Everolimus

✍ Scribed by Jean-Jacques Patard


Book ID
118440658
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
184 KB
Volume
8
Category
Article
ISSN
1569-9056

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## Abstract ## BACKGROUND: Dysregulation of phosphatase and tensin homolog (PTEN) and the gene that encodes the p110Ξ± catalytic subunit of phosphatidylinositol‐3‐kinase (PI3K), PIK3CA, are the most common mutations in endometrial carcinoma (EC). Loss of PTEN or activation of PIK3CA results in cons