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Treating hepatitis C: Can you teach old dogs new tricks?

✍ Scribed by Charles M. Rice; Shihyun You

Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 106 KB
Volume: 42
Category: Article
ISSN: 0270-9139
DOI: 10.1002/hep.20975

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✦ Synopsis

Viruses depend on host-derived factors for their efficient genome replication. Here, we demonstrate that a cellular peptidyl-prolyl cis-trans isomerase (PPIase), cyclophilin B (CyPB), is critical for the efficient replication of the hepatitis C virus genome. CyPB interacted with the HCV RNA polymerase NS5B to directly stimulate its RNA binding activity. Both the RNA interference (RNAi)-mediated reduction of endogenous CyPB expression and the induced loss of NS5B binding to CyPB decreased the levels of HCV replication. Thus, CyPB functions as a stimulatory regulator of NS5B in HCV replication machinery. This regulation mechanism for viral replication identifies CyPB as a target for antiviral therapeutic strategies.

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