Traumatic Injury Activates Protein Kinase B/Akt in Cultured Astrocytes: Role of Extracellular ATP and P2 Purinergic Receptors
β Scribed by Neary, Joseph T.; Kang, Yuan; Tran, Minh; Feld, Jonathan
- Book ID
- 121241827
- Publisher
- Mary Ann Liebert
- Year
- 2005
- Tongue
- English
- Weight
- 283 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0897-7151
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ATP-induced phosphoinositide (PI) hydrolysis was studied in cultured astrocytes. To characterize the Pz purinergic receptor-mediated effects of ATP, the subtype-specific agonists 2-methylthio ATP (2-MeSATP1, UTP, and a,P-methylene ATP were compared. ATP, UTP, or 2-MeSATP induced a dose-dependent inc
## Abstract A physiological concentration of extracellular ATP stimulated biphasic Ca^2+^ signal, and the Ca^2+^ transient was decreased and the Ca^2+^ sustain was eliminated immediately after removal of ATP and Ca^2+^ in RBAβ2 astrocytes. Reintroduction of Ca^2+^ induced Ca^2+^ sustain. Stimulatio