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Trapping of 4-hydroxynonenal by glutathione efficiently prevents formation of DNA adducts in human cells

✍ Scribed by Olivier Falletti; Jean Cadet; Alain Favier; Thierry Douki

Book ID
113630242
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
686 KB
Volume
42
Category
Article
ISSN
0891-5849

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## Abstract Naphthalene is metabolized in the lung and liver to reactive intermediates by cytochrome P450 enzymes. These reactive species deplete glutathione, covalently bind to proteins, and cause necrosis in Clara cells of the lung. The importance of glutathione loss in naphthalene toxicity was i