✦ LIBER ✦

Transverse relaxation of cells labeled with magnetic nanoparticles

✍ Scribed by C. H. Ziener; W. R. Bauer; P. M. Jakob

Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 186 KB
Volume: 54
Category: Article
ISSN: 0740-3194
DOI: 10.1002/mrm.20634

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✦ Synopsis

Abstract

We describe the NMR relaxation properties of magnetically labeled cells. The cells are labeled with magnetic nanoparticles (SPIO, USPIO), which generate susceptibility contrast. The geometry of the labeled cells and the surrounding tissue is considered. We assume that the magnetic nanoparticles accumulate to form a magnetic core of radius R~C~ inside the cell. The correlation time τ, which describes the motion of spins around this core, is analyzed. Using the strong collision approach, explicit expressions are derived for the transverse relaxation rate R for tissue containing labeled cells as a function of the core radius, the diffusion coefficient, and the concentration of the nanoparticles. The predictions of this model agree well with numerical simulations and experimental data. Magn Reson Med, 2005. © 2005 Wiley‐Liss, Inc.

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