Transposons and the Dynamic Genome

✍ Scribed by Arnaud Le Rouzic, Pierre Capy (auth.), Dirk-Henner Lankenau, Jean-Nicolas Volff (eds.)

• Publisher: Springer-Verlag Berlin Heidelberg
• Year: 2009
• Tongue: English
• Leaves: 195
• Series: Genome Dynamics and Stability 4
• Edition: 1
• Category: Library

✦ Synopsis

There are only few major key functions that lie beneath the fundamental architecture of metabolism and life. These are multiplication, variation and heredity. Only if these factors interact synergistically can Darwinian selection power the evolution of biodiversity. Transposable elements have always played a major role in this process. The genomes of all organisms consist of chromosomes that are built up of double-stranded nucleic acid chains on whose stability and integrity the existence of cells depend. While DNA repair warrants the chemical integrity of DNA and protects it from metabolic and environmental mutagens, meiotic recombination and transposable element activity appear to counteract the molecular guardians of genome stability. Transposable elements and their kind often make up the bulk of genomic DNA, often approaching 50% of the genome. By contrast, the classic genes represent as little as 1.8% of genomic DNA, in case of the human genome.

This volume gives an overview on mobile DNA and how such contradiction to the obligatory stability of genomes can be understood. Obviously, an understanding can only be achieved by cutting deeply into the evolutionary history of life along with the evolution of transposable elements and dynamic genomes.

This book therefore also celebrates Charles Darwin’s 200^th birthday. The reader is challenged to view the role of movable DNA along historical roots from the levels of cells to populations to biological species integrating the accompanying molecular evolution of host, cell and genome interaction. One will witness even the reactivation of a long since dead, fossil transposable element and the infection of germline cells by the first established, mobile and endogenous insect retrovirus.

✦ Table of Contents

Front Matter....Pages I-XVI
Theoretical Approaches to the Dynamics of Transposable Elements in Genomes, Populations, and Species....Pages 1-19
Infra- and Transspecific Clues to Understanding the Dynamics of Transposable Elements....Pages 21-43
Morphological Characters from the Genome: SINE Insertion Polymorphism and Phylogenies....Pages 45-75
Genome Defense Against Transposable Elements and the Origins of Regulatory RNA....Pages 77-94
When Drosophila Meets Retrovirology: The gypsy Case....Pages 95-107
Transposon–Host Cell Interactions in the Regulation of Sleeping Beauty Transposition....Pages 109-132
Interactions of Transposons with the Cellular DNA Repair Machinery....Pages 133-176
Back Matter....Pages 177-184

✦ Subjects

Biochemistry, general; Cell Biology; Human Genetics