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Transposition ofc-abloncogene in a case of masked Ph chromosome duplicated in blastic phase

✍ Scribed by Emanuela Maserati; P. Cavalli; R. Casalone; S. Morandi; F. Pasquali

Book ID
104707555
Publisher
Springer
Year
1988
Tongue
English
Weight
392 KB
Volume
78
Category
Article
ISSN
0340-6717

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✦ Synopsis

A female with chronic myelocytic leukemia (CML) in blastic phase (BP) showed a masked Ph chromosome that had originated by a translocation between chromosomes 8 and 22, with no obvious involvement of chromosome 9. A duplication of the masked Ph and trisomy 13 were present as additional anomalies. The karyotype on peripheral blood unstimulated cultures was 48,XX,t(8;22)(p12;q11),+13,+der(22) t(8;22)/47,XX,t(8;22)(p12;q11),+der(22)t(8;22). While the duplication of the Ph is a frequent finding in BP of CML, we did not find any other case in the literature with duplication of a masked Ph. In situ hybridization with c-abl and bcr probes showed that a 3' bcr sequence was translocated to the der(8) chromosome, while the c-abl oncogene was transposed to the masked Ph.

📜 SIMILAR VOLUMES

Direct visualization of the transposed A
Direct visualization of the transposed ABL gene in a duplicated masked Ph chromosome
✍ M. J. Macera; P. Szabo; J. H. Lin; A. T. Desalvo; H. O. Shah; Dr. R. S. Verma 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 347 KB

In a small percentage of cases of chronic myelogenous leukemia (CML), where the Ph chromosome is masked because of highly complex translocations and sub-microscopic rearrangements, precise identification of chromosomal aberrations by routine banding techniques has been difficult. We report on a new