Transposition of 9q34 and 22 (q11→qter) regions has a specific role in chronic myelocytic leukemia

✍ Scribed by F. Pasquali; R. Casalone; D. Francesconi; Diletta Peretti; M. Fraccaro; C. Bernasconi; M. Lazzarino

• Book ID: 104704517
• Publisher: Springer
• Year: 1979
• Tongue: English
• Weight: 625 KB
• Volume: 52
• Category: Article
• ISSN: 0340-6717
• DOI: 10.1007/bf00284598

✦ Synopsis

Six cases are reported of variant Ph' translocations found among 240 patients with Ph'-positive CML. Five cases had a three-chromosome rearrangement involving, in addition to chromosomes 9 and 22, chromosomes 7, 4, 2(two), and 3, respectively, and one case had a two-chromosome rearrangement 22/5. A review of the literature revealed that three- and two-chromosome variant Ph' translocations are observed with equal frequency. It is postulated that all variant translocations are indeed three-chromosome rearrangements, that the specific event for the formation of the Ph' chromosome is the reciprocal translocation 9/22, and that the transposition of regions 9q34 and 22 (q11toqter), plays a major role in the development of CML.