β Scribed by Bente Steffansen M.Sc.(Pharm), Ph.D. (auth.), Yuichi Sugiyama, Bente Steffansen (eds.)
No coin nor oath required. For personal study only.
Transporters in Drug Development examines how membrane transporters can be dealt with in academicβindustrial drug discovery and pharmaceutical development as well as from a regulatory perspective. The book describes methods and examples of in vitro characterization of single transporters in the intestines, liver and kidneys as well as characterization of substrate overlap between various transporters. Furthermore, probes and biomarkers are suggested for studies of the transportersβ impact on the pharmacokinetics of drug substrates/candidates interacting on transporters. The challenges of translating in vitro observed interaction of transporters into in vivo relevance are explored, and the book highlights perspectives of applying targeted proteomics and mechanistic modeling in this process.
Front Matter....Pages i-xiii
Membrane Transporters in ADME....Pages 1-22
In Vitro Kinetic Characterization of Transporter-Mediated Permeability....Pages 23-35
In Vitro Characterization of Interactions with Drug Transporting Proteins....Pages 37-65
In Vivo Characterization of Interactions on Transporters....Pages 67-97
Applications of Targeted Proteomics in ADME for IVIVE....Pages 99-119
Prediction of Hepatic Transporter-Mediated DrugβDrug Interaction from In Vitro Data....Pages 121-153
Accounting for Transporters in Renal Clearance: Towards a Mechanistic Kidney Model (Mech KiM)....Pages 155-177
Analysis of Intestinal Transporters....Pages 179-199
Analysis of Hepatic Transport Proteins....Pages 201-233
Analysis of Renal Transporters....Pages 235-256
The Role of Transporters in Drug Development: Regulatory Science Perspectives from the FDA....Pages 257-283
Industrial Evaluation of Drug Transporters in ADME....Pages 285-307
Erratum....Pages E1-E1
Back Matter....Pages 309-317
Pharmaceutical Sciences/Technology; Biomedicine general
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