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Transporter-mediated bile acid uptake causes Ca2+-dependent cell death in rat pancreatic acinar cells

✍ Scribed by Joo Young Kim; Kyung Hwan Kim; Jin Ah Lee; Wan Namkung; An–Qiang Sun; Meena Ananthanarayanan; Frederick J. Suchy; Dong Min Shin; Shmuel Muallem; Min Goo Lee


Book ID
119756599
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
420 KB
Volume
122
Category
Article
ISSN
0016-5085

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We have examined the effect of the Ca2+ (Mg2+)-ATPase inhibitors thapsigargin (TG) and vanadate on ATP-dependent 45Ca2+ uptake into IP3-sensitive Ca2+ pools in isolated microsomes from rat pancreatic acinar cells. The inhibitory effect of TG was biphasic. About 40-50% of total Ca2+ uptake was inhibi