Transport of Phosphatidylcholine in MDR3-Negative Epithelial Cell Lines via Drug-Induced MDR1 P-Glycoprotein
β Scribed by Abedel-nasser Ghazi Abulrob; Mark Gumbleton
- Book ID
- 115584221
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 109 KB
- Volume
- 262
- Category
- Article
- ISSN
- 0006-291X
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Drug resistance, both primary and acquired, is a major obstacle to advances in cancer chemotherapy. In vitro, multidrug resistance can be mediated by P-glycoprotein (PGY1), a cell surface phosphoglycoprotein that acts to efflux natural products from cells. PGY1 is encoded by the MDR1 gene located at