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Transport of LDS-751 from the cytoplasmic leaflet of the plasma membrane by the rhodamine-123-selective site of P-glycoprotein

โœ Scribed by Adam B. Shapiro; Victor Ling


Book ID
114429153
Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
197 KB
Volume
254
Category
Article
ISSN
1432-1327

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Bidirectional transport of rhodamine 123
โœ Fuxing Tang; Hui Ouyang; Jerry Z. Yang; Ronald T. Borchardt ๐Ÿ“‚ Article ๐Ÿ“… 2004 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 121 KB

The bidirectional permeation characteristics of rhodamine 123 and Hoechst 33342, fluorescence probes of the binding sites on P-glycoprotein (P-gp), across monolayers of MDCK cells transfected with the human MDR1 gene (MDCK-MDR1) were investigated. The ratios of the apparent permeability coefficients