Zidovudine transport in the rabbit brain
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Yanfeng Wang; Ronald J. Sawchuk
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Article
📅
1995
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John Wiley and Sons
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English
⚖ 790 KB
The distribution of zidovudine (AZT) between plasma, brain extracellular fluid (ECF), and cerebrospinal fluid (CSF) was investigated in a crossover design study (n = 5) in unanesthetized rabbits. Drug was administered by intravenous (iv) and intracerebroventricular (icv) infusions at the same infusi