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Transplantin blocks voltage-dependent calcium current in isolated cochlear outer hair cells but is not ototoxic in vivo

โœ Scribed by Takehisa Saito; Takehito Yamamoto; Zhi Jian Zhang; Takechiyo Yamada; Yasuhiro Manabe; Hitoshi Saito


Book ID
113127873
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
375 KB
Volume
697
Category
Article
ISSN
0006-8993

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Cochlear outer hair cells have been well established as primary targets of the ototoxic actions of aminoglycoside antibiotics. These cells, isolated from the guinea pig cochlea and maintained in short-term culture, were used as a model for evaluating the acute effects of gentamicin on cell viability