Transplantation of Flk-1+ human bone marrow-derived mesenchymal stem cells promotes angiogenesis and neurogenesis after cerebral ischemia in rats

Transplantation of human mesenchymal ste

Transplantation of human mesenchymal stem cells promotes functional improvement and increased expression of neurotrophic factors in a rat focal cerebral ischemia model

✍ Kiryo Wakabayashi; Atsushi Nagai; Abdullah Md. Sheikh; Yuri Shiota; Dashdemberel 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 581 KB

## Abstract Previous studies have suggested that intravenous transplantation of mesenchymal stem cells (MSCs) in rat ischemia models reduces ischemia‐induced brain damage. Here, we analyzed the expression of neurotrophic factors in transplanted human MSCs and host brain tissue in rat middle cerebra