✦ LIBER ✦

Transplacental mutagenicity of N-ethyl-N-nitrosourea at the hprt locus in T-lymphocytes of exposed B6C3F1 mice

✍ Scribed by Hillary E. Sussman; Michael J. Bauer; Xiaochu Shi; Stephen A. Judice; Richard J. Albertini; Vernon E. Walker

Publisher: John Wiley and Sons
Year: 2001
Tongue: English
Weight: 100 KB
Volume: 38
Category: Article
ISSN: 0893-6692
DOI: 10.1002/em.1047

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Mutational response at the splenic T-Lym

Mutational response at the splenic T-Lymphocyte hprt locus in mice treated as neonates: Contrasting effects of the carcinogens N-ethyl-N-nitrosourea, dimethylnitrosamine, and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine

✍ S. Balachandra Dass; Robert H. Heflich; Daniel A. Casciano 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 138 KB 👁 2 views

The newborn mouse tumorigenicity assay, which reached 155.1 1 10 06 following a cumulative dose involves the treatment of animals during the first two of 49 mg ENU/kg body weight and 172.3 1 10 06 weeks after birth and monitoring tumor induction following a cumulative dose of 142 mg ENU/kg. after a

Detection of cyclophosphamide-induced mu

Detection of cyclophosphamide-induced mutations at the Hprt but not the lacI locus in splenic lymphocytes of exposed mice

✍ Vernon E. Walker; Julie L. Andrews; Patricia B. Upton; Thomas R. Skopek; Johan G 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 129 KB 👁 2 views

The relative sensitivities and specificities of the endogenous Hprt gene and the lacI transgene as mutational targets were evaluated in splenic lymphocytes from male standard B6C3F1 mice (only Hprt assayed) and from lacI transgenic B6C3F1 mice treated at 6 -7 weeks-of-age with the indirectacting age

Molecular analysis of in vivo mutations

Molecular analysis of in vivo mutations induced by N-ethyl-N-nitrosourea in the autosomal Tk and the X-linked Hprt genes of mouse lymphocytes

✍ Vasily N. Dobrovolsky; Tao Chen; Robert H. Heflich 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 146 KB 👁 2 views

The endogenous, autosomal Tk gene is a potentially useful reporter of in vivo mutation since it may recover a wider range of mutational events than the X-linked Hprt gene or bacterial transgenes. In this study, we characterized mutations produced in the Tk gene of Tk ϩ/Ϫ mice and compared them with

Characterization of Hprt mutations in cD

Characterization of Hprt mutations in cDNA and genomic DNA of T-cell mutants from control and 1,3-butadiene-exposed male B6C3F1 mice and F344 rats

✍ Quanxin Meng; Dale M. Walker; Bobby R. Scott; Steve K. Seilkop; James K. Aden; V 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 189 KB 👁 1 views

System Issues: Mutagenic response of the

System Issues: Mutagenic response of the endogenous hprt gene and lacl transgene in benzo[a]pyrene-treated Big Blue™ B6C3F1 mice

✍ Thomas R. Skopek; Kristy L. Kort; Deborah R. Marino; Lakshmi V. Mittal; Diane R. 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 807 KB

Big Blue@ (BB) and generic B6C3F1 mice were given one to three i.p. injections of 50 mg/kg benzo[a]pyrene (B[a]P) in DMSO every other day to achieve cumulative doses of 50 to 150 mg/kg. Three weeks after treatment, the mutation frequency at the endogenous hprt gene and lac/ transgene was measured in