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Transplacental induction of lymphomas in Swiss mice by carbendazim and sodium nitrite

✍ Scribed by Mátyás Börzsönyi; Alán Pintér; András Surján; Ilona Farkas

Book ID
102864492
Publisher
John Wiley and Sons
Year
1976
Tongue
French
Weight
770 KB
Volume
17
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Swiss mice at different stages of pregnancy were treated intragastrically with the pesticide Carbendazim (MBC., BCM, methyl‐2‐benzimidazole carbamate) together with sodium nitrite. Lymphomas developed in 33.3% of young mice whose mothers were treated in the first week of pregnancy, in 53.3 % of those whose mothers were treated during the second week, and in 38.8% of those born of mothers treated during the third week. Treatment during the whole period of pregnancy yielded on an average 70.0% malignancy in offspring. However, administration of Carbendazim by itself did not produce lymphomas in the first generation. In lymphomas induced by in vivo‐formed N‐nitroso compounds, A‐ and C‐type oncornavirus particles were observed with the electron microscope.

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