Transoral CO2 laser treatment for Tis–T3 glottic cancer: The University of Brescia experience on 595 patients
✍ Scribed by Giorgio Peretti; Cesare Piazza; Daniela Cocco; Luigi De Benedetto; Francesca Del Bon; Luca Oscar Redaelli De Zinis; Piero Nicolai
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 89 KB
- Volume
- 32
- Category
- Article
- ISSN
- 1043-3074
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✦ Synopsis
Abstract
Background
Transoral CO~2~ laser surgery has been accepted as a valuable therapeutic option for glottic cancer.
Methods
This was a retrospective analysis of 595 patients. Five‐year overall and disease‐specific survivals, local control with laser, locoregional, regional control, and organ preservation rates were calculated. The impact of different variables was calculated by univariate analysis.
Results
Overall, disease‐specific and disease‐free survivals, local control with laser, locoregional, regional control, and organ preservation rates were 87.5%, 99%, 81.3%, 92.7%, 98.9%, 98.2%, and 97.1%, respectively. Univariate analysis showed a significant impact of pT category on local control with laser, organ preservation, locoregional and regional control, of endoscopic re‐treatment for positive deep surgical margins on local control with laser and organ preservation, and recurrence after endoscopic re‐treatment on local control with laser and organ preservation.
Conclusion
This series confirms the good oncologic outcomes of endoscopic laser surgery for T~is~, T~1~, and selected T~2~ and T~3~ glottic tumors. © 2009 Wiley Periodicals, Inc. Head Neck, 2010