𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Transmission of the PiZallele for α1-antitrypsin deficiency: Population genetic considerations

✍ Scribed by R. Chakraborty; J. Constans; P. P. Majumder

Publisher
Springer
Year
1982
Tongue
English
Weight
442 KB
Volume
62
Category
Article
ISSN
0340-6717

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

The molecular genetics of α1 antitrypsin
The molecular genetics of α1 antitrypsin deficiency
✍ Ying Wu; Richard C. Foreman 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 882 KB

The human serum protein u,-antitrypsin is the major source of antiprotease activity found in the blood. The protein is synthesised primarily by liver cells but, to a lesser extent, by at least one other cell type. Expression of the gene has provided a paradigm for studies on transcriptional regulati

Population genetics of α1-Antitrypsin in
Population genetics of α1-Antitrypsin in the Netherlands
✍ E. C. Klasen; C. Franken; W. S. Volkers; L. F. Bernini 📂 Article 📅 1977 🏛 Springer 🌐 English ⚖ 577 KB

Two groups of 708 healthy blood donors and 563 patients affected with chronic obstructive lung disease (C.O.L.D.) respectively, have been screened for al-antitrypsin (alAT) variants by electrophoresis on agarose-polyacrylamide gels at pH 4.7 and isoelectric focusing (IEF). The frequencies of the Pi

Biochemical intermediates in α1-antitryp
Biochemical intermediates in α1-antitrypsin deficiency: Residual family resemblance for total α1-antitrypsin, oxidized α1-antitrypsin, and immunoglobulin E after adjustment for the effect of the Pi locus
✍ E. K. Silverman; M. A. Province; E. J. Campbell; J. A. Pierce; D. C. Rao; N. G. 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 812 KB

## Louis a,-antitrypsin (a1 AT) deficiency is variably associated with the development of pulmonary emphysema. To gain insight into the process which begins the Z point mutation at the Protease Inhibitor (Pi) locus and results in the variable development of emphysema, three quantitative phenotypes