Transmission of mitochondrial DNA - playing favorites?
β Scribed by Jeffrey L. Boore
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 490 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0265-9247
No coin nor oath required. For personal study only.
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## Abstract By using a combination of Southern blot hybridization analysis, polymeraseβchain reaction amplification, and direct nucleotide sequencing, we studied deletions of mitochondrial DNA (mtDNA) in several nonfamilial patients with progressive external ophthalmoplegia and KearnsβSayre syndrom
In 2002, paternal inheritance of muscle mitochondrial DNA (mtDNA) was reported in a patient with exercise intolerance and a mitochondrial DNA (mtDNA) mutation restricted to skeletal muscle. To evaluate whether paternal inheritance is a common phenomenon, we studied 10 sporadic patients with skeletal