Transmission electron microscopy of frozen hydrated biological material
β Scribed by Murray Stewart
- Publisher
- Elsevier Science
- Year
- 1989
- Weight
- 441 KB
- Volume
- 2
- Category
- Article
- ISSN
- 0892-0354
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Transmission electron microscopy (TEM) and its facility for electron diffraction has long been a key technique in materials science. Its use for characterization of pharmaceutical samples has, however, been very limited, largely due to the difficulties associated with the preparation of appropriatel
## Abstract Elemental microanalysis of biological material in the frozenβhydrated state using inβvacuum proton induced Xβray emission is described for the first time. For this purpose, a commercially available cryotransfer system was modified and coupled to the experimental chamber of the nuclear m