Transmission and Dynamics of Tuberculosis on Generalized Households

✍ Scribed by JUAN P APARICIO; ANGEL F CAPURRO; CARLOS CASTILLO-CHAVEZ

• Book ID: 102612648
• Publisher: Elsevier Science
• Year: 2000
• Tongue: English
• Weight: 220 KB
• Volume: 206
• Category: Article
• ISSN: 0022-5193
• DOI: 10.1006/jtbi.2000.2129

✦ Synopsis

Tuberculosis (TB) transmission is enhanced by systematic exposure to an infectious individual. This enhancement usually takes place at either the home, workplace, and/or school (generalized household). Typical epidemiological models do not incorporate the impact of generalized households on the study of disease dynamics. Models that incorporate cluster (generalized household) e!ects and focus on their impact on TB's transmission dynamics are developed. Detailed models that consider the e!ect of casual infections, that is, those generated outside a cluster, are also presented. We "nd expressions for the Basic Reproductive Number as a function of cluster size. The formula for R separates the contributions of cluster and casual infections in the generation of secondary TB infections. Relationships between cluster and classical epidemic models are discussed as well as the concept of critical cluster size.