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Transmissible and genetic prion diseases share a common pathway of neurodegeneration

✍ Scribed by Lingappa, Vishwanath R.; Hegde, Ramanujan S.; Tremblay, Patrick; Groth, Darlene; DeArmond, Stephen J.; Prusiner, Stanley B.

Book ID
109819352
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
299 KB
Volume
402
Category
Article
ISSN
0028-0836

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Five haploid monokaryons of the basidiomycete Coprinus cinereus were already known to be unable to form sclerotia (asexual resting structures) on the vegetative monokaryotic mycelium. Genetic analyses had shown that four distinct genes (symbolised scl were represented, all being "recessive" to their