Transmembrane Signalling

✍ Scribed by Patrick Barton; Christopher A. Hunter; Timothy J. Potter; Simon J. Webb; Nicholas H. Williams

• Book ID: 101372929
• Publisher: John Wiley and Sons
• Year: 2002
• Tongue: English
• Weight: 112 KB
• Volume: 114
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/1521-3757(20021018)114:20<4034::aid-ange4034>3.0.co;2-v

✦ Synopsis

Cells are separated from their surroundings by a lipid bilayer membrane, yet their survival depends on their ability to sense and respond to changes in the environment such as the levels of extracellular hormones, growth factors, cytokines, nutrients, and pathogens. One way in which these molecular signals can change the intracellular chemistry is by being transported into the cell through active transport or pores in the membrane. To date, synthetic approaches to communication across lipid membranes have relied on mimicking this direct physical transport of the molecular signal across the ZUSCHRIFTEN 4034