Translocation t(8;22) in peripheral lymphocytes and established lymphoid cell lines from a patient with Hodgkin's disease followed by acute lymphatic leukemia
✍ Scribed by Dr. Christa Fonatsch; Heinz Burrichter; Michael Schaadt; Hartmut H. Kirchner; Volker Diehl
- Publisher
- John Wiley and Sons
- Year
- 1982
- Tongue
- French
- Weight
- 664 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
Abstract
Cytogenetic studies on primary material and established cell lines of a patient with B‐cell non‐Hodgkin Lymphoma with leukemic presentation as secondary malignancy after Hodgkin's disease clearly revealed correspondent marker chromosomes in both culture systems. A translocation t(8;22) which has been described in some cases of non‐endemic Burkitt's lymphoma as a variant of the translocation t(8;14) was found in all metaphases of the cell lines and in most of the cells of the primary material. In addition, structural aberrations involving chromosomes 1, 2, 3 and 11, as well as numerical deviations concerning chromosomes 2, 4, 7 and Y, could be observed. The cytogenetical findings are discussed in relation to clinical, immunological and cytochemical data.