Translocation t(1;17)(q12;q25) with a clinical picture like of a proximal deletion of 1q: identification by in situ hybridization with chromosome 1-specific satellite DNA probes

✍ Scribed by Swetlana G. Vorsanova; Y. B. Yurov; M. B. Kurbatov; L. Z. Kazantzeva

• Publisher: Springer
• Year: 1990
• Tongue: English
• Weight: 189 KB
• Volume: 86
• Category: Article
• ISSN: 0340-6717
• DOI: 10.1007/bf00197700

✦ Synopsis

The authors report a case of a balanced 1;17 translocation with breakpoints located in the secondary constriction of chromosome 1. This translocation is associated with pathological symptoms similar to those observed following a proximal deletion of lq. We request contact with colleques who have observed similar, or related, cases of translocation with breakpoints in heterochromatic regions of human chromosomes.