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Translocation of protein kinase C in rat islets of Langerhans Effects of a phorbol ester, carbachol and glucose

โœ Scribed by Shanta J. Persaud; Peter M. Jones; David Sugden; Simon L. Howell


Book ID
115921560
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
445 KB
Volume
245
Category
Article
ISSN
0014-5793

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## Abstract Stimulation of chief cells with carbachol or cholecystokinin (CCK) results in the production of inositol trisphosphate (IP~3~) and diacylglycerol (DAG). Although IP~3~ increases cell calcium concentration, thereby stimulating pepsinogen secretion, the role of DAG and its target, protein