Translocation of BCR to chromosome 9 in a Philadelphia-negative chronic myeloid leukemia
✍ Scribed by Véronique Brunel; Danielle Sainty; Régis Costello; Marie-Joëlle Mozziconacci; Jacqueline Simonetti; Christine Arnoulet; Lionel Coignet; Reda Bouabdallah; Jean-Albert Gastaut; Jean Gabert; Marina Lafage-Pochitaloff
- Book ID
- 113253598
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 479 KB
- Volume
- 85
- Category
- Article
- ISSN
- 0165-4608
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📜 SIMILAR VOLUMES
Chronic myeloid leukemia consists of Philadelphia chromosome positive disease in 90% of cases, and a further 5%, although Philadelphia chromosome negative, exhibit bcr gene rearrangements consistent with the disease. The remaining 5% of cases have a heterogeneous clinical picture with a course unlik
## Abstract Leukemic cells from two patients with Philadelphia‐negative chronic myeloid leukemia (CML) were investigated: I) Cytogenetics showed a normal 46.XY karyotype in both cases, 2) molecular studies revealed rearrangement of the M‐BCR region and formation of __BCR‐ABL__ fusion mRNA with b2a2