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Translocation (10;21)(q21;q22) in myelodysplastic syndrome

โœ Scribed by Zjir Rashaan; Yoshikazu Ito; Tomoiku Takaku; Juri Toyotake; Keisuke Miyazawa; Atsushi Kodama; Kazuma Ohyashiki


Book ID
113513035
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
157 KB
Volume
173
Category
Article
ISSN
0165-4608

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A family is described with a translocation t(10;21)(q22;q22) transmitted through three generations. This family was studied for the apparition of several miscarriages and two sisters with multiple malformations. Both children had a probably partial trisomy of chromosome 10 and a monosomy of chromoso

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## An article by Steinberg et a1 [1984] cautioned against the potential error of counseling families a low-recurrence risk when a previous child has had a de novo 21q21q translocation Down syndrome. They also studied 112 families (ie, sets of parents) with a child with de novo 21q21q translocatio