Choline antagonism of methotrexate liver
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Freeman-Narrod, M. ;Narrod, S. A. ;Yarbro, J. W.
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Article
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1977
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John Wiley and Sons
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English
β 404 KB
## Abstract Because of the frequent reports of hepatic toxicity associated with longβterm administration of methotrexate, a rat model was developed utilizing daily methotrexate administration. This model revealed an incidence of fatty metamorphosis of over 80 percent, atrophy and necrosis of 30 per