Translational Stroke Research: From Target Selection to Clinical Trials

✍ Scribed by Sara Morales Palomares PhD, Marilyn J. Cipolla PhD (auth.), Paul A. Lapchak, John H. Zhang (eds.)

• Publisher: Springer-Verlag New York
• Year: 2012
• Tongue: English
• Leaves: 926
• Series: Springer Series in Translational Stroke Research
• Edition: 1
• Category: Library

✦ Synopsis

This volume sets a basis for effective translational research. Authored by experts in the field of translational stroke research, each chapter specifically addresses one or more components of preclinical stroke research. The emphasis is placed on target identification and drug development using state-of-the-art in vitro and in vivo assays, in combination with in vitro toxicology assays, AMDE and clinical design.

✦ Table of Contents

Front Matter....Pages i-xxiv
Front Matter....Pages 1-1
Vascular Targets for Ischemic Stroke Treatment....Pages 3-36
Identifying Vascular Targets to Treat Hemorrhagic Stroke....Pages 37-55
Experimental Platforms for Assessing White Matter Pathophysiology in Stroke....Pages 57-78
Neuroprotection in Stroke....Pages 79-97
Front Matter....Pages 99-99
Protein Aggregation and Multiple Organelle Damage After Brain Ischemia....Pages 101-116
Antioxidants and Stroke: Success and Pitfalls....Pages 117-143
Caspase-Independent Stroke Targets....Pages 145-174
Hypoxia-Inducible Factor: A New Hope to Counteract Stroke....Pages 175-188
Thrombin in Ischemic Stroke Targeting....Pages 189-204
Toll-Like Receptor Agonists as Antecedent Therapy for Ischemic Brain Injury: Advancing Preclinical Studies to the Nonhuman Primate....Pages 205-230
Angiogenesis and Arteriogenesis as Stroke Targets....Pages 231-249
Hematopoietic Growth Factor Family for Stroke Drug Development....Pages 251-276
Soluble Epoxide Hydrolase as a Stroke Target....Pages 277-294
Membrane Potential as Stroke Target....Pages 295-303
Hypothermia to Identify Therapeutic Targets for Stroke Treatment....Pages 305-320
Stroke Preconditioning to Identify Endogenous Protective or Regenerative Mechanisms....Pages 321-334
microRNAs in Ischemic Brain: The Fine-Tuning Specialists and Novel Therapeutic Targets....Pages 335-352
Neuroglobin: A Novel Target for Endogenous Neuroprotection....Pages 353-372
Characterization of Novel Neuroprotective Lipid Analogues for the Treatment of Stroke....Pages 373-385
Na + /H + Exchangers as Therapeutic Targets for Cerebral Ischemia....Pages 387-401
Front Matter....Pages 99-99
Iron as a Therapeutic Target in Intracerebral Hemorrhage: Preclinical Testing of Deferoxamine....Pages 403-416
Potential Therapeutic Targets for Cerebral Resuscitation After Global Ischemia....Pages 417-450
The Splenic Response to Ischemic Stroke: Neuroinflammation, Immune Cell Migration, and Experimental Approaches to Defining Cellular Mechanisms....Pages 451-468
Front Matter....Pages 469-469
Overcoming Barriers to Translation from Experimental Stroke Models....Pages 471-492
Animal Models of Stroke for Preclinical Drug Development: A Comparative Study of Flavonols for Cytoprotection....Pages 493-524
Clinical Relevance in a Translational Rodent Model of Acute Ischemic Stroke: Incorporating the Biological Variability of Spontaneous Recanalization....Pages 525-540
A Clinically Relevant Rabbit Embolic Stroke Model for Acute Ischemic Stroke Therapy Development: Mechanisms and Targets....Pages 541-584
Animal Models of Intracranial Aneurysms....Pages 585-593
Animal Models of SAH and Their Translation to Clinical SAH....Pages 595-613
Front Matter....Pages 615-615
ADME (Absorption, Distribution, Metabolism, Excretion): The Real Meaning—Avoiding Disaster and Maintaining Efficacy for Preclinical Candidates....Pages 617-638
CeeTox Analysis to De-risk Drug Development: The Three Antioxidants (NXY-059, Radicut, and STAZN)....Pages 639-656
Front Matter....Pages 657-657
Site-Specific, Sustained-Release Drug Delivery for Subarachnoid Hemorrhage....Pages 659-680
Therapeutic Potential of Intranasal Delivery of Drugs and Cells for Stroke and Other Neurological Diseases....Pages 681-688
Front Matter....Pages 689-689
High-Dose Albumin for Neuroprotection in Acute Ischemic Stroke: From Basic Investigations to Multicenter Clinical Trial....Pages 691-719
The Translation Procedure of Low-Level Laser Therapy in Acute Ischemic Stroke: A Nonpharmaceutics Noninvasive Method....Pages 721-743
Use of Microbubbles in Acute Stroke....Pages 745-752
Transcranial High-Intensity Focused Ultrasound for Sonothrombolysis in Stroke....Pages 753-776
Cellular Therapy for Ischemic Stroke....Pages 777-814
Front Matter....Pages 815-815
Repair-Based Therapies After Stroke....Pages 817-831
A Critical Review of Stroke Trial Analytical Methodology: Outcome Measures, Study Design, and Correction for Imbalances....Pages 833-861
Front Matter....Pages 815-815
Metabolic Imaging in Translational Stroke Research....Pages 863-879
Computational Analysis: A Bridge to Translational Stroke Treatment....Pages 881-909
Innovations in Stroke Clinical Trial Design....Pages 911-916
Back Matter....Pages 917-923

✦ Subjects

Neurosciences; Neurobiology