✦ LIBER ✦

Translational repression as a conserved mechanism for the regulation of embryonic polarity

✍ Scribed by Daniel Curtis

Publisher: John Wiley and Sons
Year: 1994
Tongue: English
Weight: 632 KB
Volume: 16
Category: Article
ISSN: 0265-9247
DOI: 10.1002/bies.950161003

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✦ Synopsis

The mechanisms used to establish embryonic polarity are still largely unknown. A recent paper(l) describes the expression pattern of the geneglp-I, which is required for induction events during development of the nematode Caenorhabditis elegans. Although glp-I RNA is found throughout the early embryo, Glp-1 protein is only expressed in anterior cells. This negative translational regulation in posterior cells is shown to be mediated through sequences in the glp-I 3'untranslated region (3'UTR). Thus in nematodes, as in Drosophila, translational repression is one mechanism used to establish the embryonic anterior-posterior axis.

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