This first-of-its-kind resource on multimodal optical imaging provides a rigorous treatment of the various techniques together with the latest clinical advances in cancer detection and other important applications. Engineers and researchers find full details on the principles, instrumentation, and methods of in vivo microscopy, optical coherence tomography, Endoscopy, and diffuse optical techniques. Supported with 119 illustrations, this milestone work: discusses key optical imaging techniques in self-contained chapters; describes the integration of optical imaging techniques with other modalities like MRI, X-ray imaging, and PET imaging; provides a software platform for multimodal integration; presents cutting-edge computational and data processing techniques that ensure rapid, cost-effective, and precise quantification and characterization of the clinical data; covers advances in photodynamic therapy and molecular imaging; and reviews key clinical studies in optical imaging along with regulatory and business issues.A CD-ROM is included and contains three freely installable software platforms for development of advanced applications as well as full-color images that further illustrate topics discussed in the book. This is the first book to provide an expert and timely comprehensive overview of the present and future outlook of clinical multimodality optical imaging from the academic to the industrial perspective. Written by pioneers in the field, it will become a useful reference to clinicians and nonclinicians, researchers, scientists, educators, and students . Britton Chance, Ph.D., Sc.D.