## BACKGROUND. When resting cells are stimulated by growth factors, an increase in protein synthesis follows that depends in part on two key eukaryotic translation initiation factors, 4E and 2โฃ (eIF-4E and eIF-2โฃ, respectively). In the normal cell, expression and activity of both factors are incre
โฆ LIBER โฆ
Translation initiation factor eIF-4G is immunogenic, overexpressed, and amplified in patients with squamous cell lung carcinoma
โ Scribed by Christine Bauer; Isabel Diesinger; Nicole Brass; Helmut Steinhart; Heinrich Iro; Eckart U. Meese
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 151 KB
- Volume
- 92
- Category
- Article
- ISSN
- 0008-543X
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## Abstract Previously, we reported gene amplification at chromosome 3q26โ27 in more than one third of squamous cell carcinomas of the lung. Frequent amplification of eukaryotic translation initiation factor 4G on 3q27.1 indicated a possible role of this amplification in translation initiation. The