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Translating Sleeping Beauty transposition into cellular therapies: Victories and challenges

✍ Scribed by Zsuzsanna Izsvák; Perry B. Hackett; Laurence J. N. Cooper; Zoltán Ivics


Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
416 KB
Volume
33
Category
Article
ISSN
0265-9247

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Translating Sleeping Beauty transpositio
✍ Zsuzsanna Izsvák; Perry B. Hackett; Laurence J.N. Cooper; Zoltán Ivics 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 368 KB

## Abstract Recent results confirm that long‐term expression of therapeutic transgenes can be achieved by using a transposon‐based system in primary stem cells and __in vivo__. Transposable elements are natural DNA transfer vehicles that are capable of efficient genomic insertion. The latest genera