## Abstract Pharmaceutical approaches to slow the progression of Alzheimer's disease (AD) have focused primarily on reducing production or increasing clearance of amyloid Ξ² peptide (AΞ²). Recent clinical trial results question the efficacy of targeting AΞ² for treatment of mild to moderate AD, highli
Translating cell biology into therapeutic advances in Alzheimer's disease
β Scribed by Selkoe, Dennis J.
- Book ID
- 109800172
- Publisher
- Nature Publishing Group
- Year
- 1999
- Tongue
- English
- Weight
- 316 KB
- Volume
- 399
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/399a023
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## Abstract Alzheimer's disease (AD) is a dementing neurodegenerative disorder without a cure. The abnormal parenchymal accumulation of Ξ²βamyloid (AΞ²) is associated with inflammatory reactions involving microglia and astrocytes. Increased levels of AΞ² and AΞ² deposition in the brain are thought to c
Clinical trials in Alzheimer's disease (AD) with first generation muscarinic agonists (e.g., arecoline, oxotremorine, pilocarpine) produced inconsistent results due to poor pharmacokinetic properties and a lack of separation between central and peripheral activities observed with these compounds. Se