𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Translating cell biology into therapeutic advances in Alzheimer's disease

✍ Scribed by Selkoe, Dennis J.


Book ID
109800172
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
316 KB
Volume
399
Category
Article
ISSN
0028-0836

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Advances in the development of kinase in
✍ Mary J. Savage; Diane E. Gingrich πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 576 KB

## Abstract Pharmaceutical approaches to slow the progression of Alzheimer's disease (AD) have focused primarily on reducing production or increasing clearance of amyloid Ξ² peptide (AΞ²). Recent clinical trial results question the efficacy of targeting AΞ² for treatment of mild to moderate AD, highli

The role and therapeutic potential of mo
✍ Tarja Malm; Milla Koistinaho; Anu Muona; Johanna Magga; Jari Koistinaho πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 295 KB πŸ‘ 1 views

## Abstract Alzheimer's disease (AD) is a dementing neurodegenerative disorder without a cure. The abnormal parenchymal accumulation of β‐amyloid (AΞ²) is associated with inflammatory reactions involving microglia and astrocytes. Increased levels of AΞ² and AΞ² deposition in the brain are thought to c

Development of M1 subtype selective musc
✍ R.D. Schwarz; M.J. Callahan; R.E. Davis; J.C. Jaen; H. Tecle πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 131 KB πŸ‘ 2 views

Clinical trials in Alzheimer's disease (AD) with first generation muscarinic agonists (e.g., arecoline, oxotremorine, pilocarpine) produced inconsistent results due to poor pharmacokinetic properties and a lack of separation between central and peripheral activities observed with these compounds. Se