✦ LIBER ✦
Transketolase-Mediated Synthesis of 4-Deoxy-D-fructose 6-Phosphate by Epoxide Hydrolase-Catalysed Resolution of 1,1-Diethoxy-3,4-epoxybutane
✍ Scribed by Christine Guérard; Véronique Alphand; Alain Archelas; Colette Demuynck; Laurence Hecquet; Roland Furstoss; Jean Bolte
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 235 KB
- Volume
- 1999
- Category
- Article
- ISSN
- 1434-193X
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✦ Synopsis
4-Deoxy-D-fructose 6-phosphate is synthesised from deoxy-D-erythrose 4-phosphate. In the last step, transketolase transfers a hydroxyacetyl group from L- nonnatural sources in four steps, including two enzymatic reactions.
(3S)-1,1-Diethoxy-3,4-epoxybutane is first erythrulose onto this aldehyde, controlling the second asymmetric center. obtained by epoxide hydrolase-catalysed resolution. Opening of this epoxide by inorganic phosphate leads to 2from hydroxypyruvate onto aldehydes, accepts racemic (2- [a