amount. Immunostaining for cytokeratins 7 and 20 was performed. of Texas Southwestern Medical Center, Dallas, RESULTS. Among the 8 women with primary endometrial tumors, the mean age Texas.
was 61.6 years (range, 41-83 years). Uterine bleeding was the presenting symptom in 7 women. Macroscopically, the tumors were polypoid, and infiltrated the myometrium, although the extent of infiltration varied. Seven endometrial tumors showed a papillary component. TCC was always admixed with other patterns (predominantly squamous, but also endometrioid, papillary, and serous patterns), with the proportion of the TCC component ranging from 5% to 95% (mean, 63.8%).
TCC was the main invasive pattern observed in all three of the cases that had deep myometrial invasion; these cases also had vascular invasion. Seven tumors were confined to the uterus; one was metastatic to the ovary. The ovarian TCC metastatic to the endometrium had a pure TCC pattern. Five of 7 cases of TCC had cytokeratin 7//200 immunoreactivity; 2 cases were cytokeratin 70/200. Treatment of primary endometrial tumors was mainly surgical, with adjuvant radiation therapy in 4 cases or chemotherapy in 1 case. Survival ranged from 3 months to 12.9 years (mean, 5.1 years). Of five women for whom follow-up was available, three were alive with no evidence of disease, one was alive with a local recurrence, and one died of Presented in abstract form at a meeting of the unrelated disease. United States and Canadian Academy of Pathol-CONCLUSIONS. TCC is a rare, distinct subtype of endometrial carcinoma with morogy, Washington, DC, March 23-29, 1996. phologic features of urothelial differentiation, but retention of a mu Β¨llerian immuno-The opinion and assertions contained herein are profile. While the overall prognosis does not appear to be worse than what might the private views of the authors and are not to be anticipated for the stage of tumor present, TCC appears to be the more aggressive be construed as official or as representing the histologic subtype among the patterns with which it is admixed. Cancer views of the Department of the Army or the 1997;79:1933-43.