✦ LIBER ✦
Transition-state stabilization via dynamic molecular recognition : a concerted acid-base bifunctional catalysis in ester hydrolysis
✍ Scribed by Tadahiro Motomura; Kazuhisa Inoue; Kenji Kobayashi; Yasuhiro Aoyama
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- French
- Weight
- 302 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
An imidazole derivative la having a bisresorcinol moiety catalyzes the hydrolysis of p-nitrophenyl acetate in H&-CHXN (9:l) bv the mechanism involvine a concerted acid-base coooeration: nucleouhilic attack of the imi&>olyl &oup bn substrate is assisted by the hidroxyl group of the bisreiorcinol 'moiety as a general acid.