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Transition-metal-mediated reactions in combinatorial synthesis

✍ Scribed by CJ Andres; Darren L Whitehouse; Milind S Deshpande

Book ID
104415004
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
610 KB
Volume
2
Category
Article
ISSN
1367-5931

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✦ Synopsis

Transition-metal-mediated reactions have played an important role in expanding the scope of combinatorial chemistry from synthesis of peptidic libraries to synthesis of nonoligomeric, small-molecule libraries. Versatile reactions such as heteroannulations, olefin metathesis and dipolar cycloadditions are used for preparation of libraries of historical, as well as novel, pharmacophores. Transition-metal-mediated reactions have also been used strategically to provide traceless linkers' in solid-phase synthesis.

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## Abstract For Abstract see ChemInform Abstract in Full Text.

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