Transition-Metal-Free Sonogashira-Type Coupling Reactions in Water

✍ Scribed by Prasad Appukkuttan; Wim Dehaen; Erik Van der Eycken

• Publisher: John Wiley and Sons
• Year: 2003
• Tongue: English
• Weight: 93 KB
• Volume: 2003
• Category: Article
• ISSN: 1434-193X
• DOI: 10.1002/ejoc.200300587

✦ Synopsis

Abstract

Microwave‐assisted transition‐metal‐free Sonogashira‐type coupling reactions are described. The reactions are run in water as the sole solvent, without the need for copper(I) or any transition‐metal−phosphane complex. The scope of the methodology was tested by reaction of a wide variety of aryl halides and heteroaryl halides. The reaction was also investigated under conventional heating conditions. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)