Transition metal free reductive dimerization of nitrogen containing barbituric acid benzylidenes

✍ Scribed by Branko S. Jursic; Edwin D. Stevens

• Publisher: Journal of Heterocyclic Chemistry
• Year: 2003
• Tongue: English
• Weight: 94 KB
• Volume: 40
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.5570400423

✦ Synopsis

Abstract

Through the NMR monitoring of the reactive intermediates in the condensation of barbituric acid with nitrogen containing heterocyclic 2‐carboxaldehydes, a synthetic procedure was developed for the preparation of each of the intermediates. The simple high yield procedure for the preparation of the reductive dimer from corresponding barbituric acid benzylidenes was developed, although we were not able to elucidate the source of the reduction. The structure of the dimer was confirmed by X‐ray analysis.