✦ LIBER ✦

Transition metal complexes in organic synthesis, part 59.1 First enantioselective total synthesis of lavanduquinocin, a potent neuronal cell protecting substance from Streptomyces viridochromogenes

✍ Scribed by Hans-Joachim Knölker; Elke Baum; Kethiri R. Reddy

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 130 KB
Volume: 12
Category: Article
ISSN: 0899-0042
DOI: 10.1002/(sici)1520-636x(2000)12:5/6<526::aid-chir40>3.0.co;2-f

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✦ Synopsis

Using (R)-propene oxide as a chiral building block a convergent enantioselective synthesis of the potent neuronal cell protecting alkaloid lavanduquinocin has been accomplished by the iron-mediated one-pot construction of the carbazole framework.