Transition metal catalysed cross-coupling between benzylic halides and aryl nucleophiles. Synthesis of some toxicologically interesting tetrachlorobenzyltoluenes.

✍ Scribed by Robert-Jan de Lang; Marcel J.C.M. van Hooijdonk; Lambert Brandsma; Hester Kramer; Willem Seinen

• Book ID: 104209144
• Publisher: Elsevier Science
• Year: 1998
• Tongue: French
• Weight: 703 KB
• Volume: 54
• Category: Article
• ISSN: 0040-4020
• DOI: 10.1016/s0040-4020(98)83030-5

✦ Synopsis

The aryl-benzyl cross-coupling in the lm~atce of copper., nickel-and I~_n~_'um-calalysts has been investigated with a number of chlorine-and methyl-substituted arylmeta/comlmmsds ArM (M= MgBr, ZnCI) amt (substituted) benzylic halides A~CH2X. The results have beca applied in the selective synthesis of some toxicologically in~m~ing tctmchloco~nzyltoluenes.