Abstract
Purpose
To test the hypothesis that flow measurements using continuous arterial spin labeling (CASL) magnetic resonance imaging (MRI) in muscle depend upon transit delay, and examine the repeatability of CASL measurements.
Materials and Methods
A total of 23 healthy subjects underwent CASL imaging of the calf, foot, and forearm with varying postlabeling delay (PLD = 1000, 1500, and 1900 msec). Experiments were conducted on a 3.0T system. An orthopedic tourniquet system was employed to create a fiveโminute period of ischemia followed by a transient hyperemic flow. Imaging commenced two minutes prior to cuff inflation and ended three minutes after cuff release.
Results
CASL was found able to well resolve the time course of the hyperemic flow pattern with an effective TR of 16 seconds, although we were unable to establish that a plateau had been reached in the flow measurements even at a PLD as long as 1900 msec. Peak hyperemic flow measurements compared favorably with those obtained with contrastโenhanced (CE) MRI following a similar period of ischemia. Regionโofโinterest (ROI)โbased repeated measurements varied by approximately 20% over a period of one hour.
Conclusion
In all anatomic regions studied, flow measurements were found to increase with PLD, suggesting the prolonged transit delay in muscle. J. Magn. Reson. Imaging 2008;28:445โ452. ยฉ 2008 WileyโLiss, Inc.