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Transient transcriptional inhibition of the transferrin gene by cyclic AMP

✍ Scribed by David Tuil; Sophie Vaulont; Mariano J. Levin; Arnold Munnich; Martine Moguilewsky; Marie M. Bouton; Pierre Brissot; Jean-Claude Dreyfus; Axel Kahn


Book ID
115917320
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
469 KB
Volume
189
Category
Article
ISSN
0014-5793

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The treatment of rat glioma C6 cells with 10 pM isoproterenol (Ipt) for 4 days upregulated the expression of the myelin-associated glycoprotein (MAG) gene by approximately 55-fold over the control value. The constant presence of Ipt in the medium was required for the maximal upregulation, as time-re