Nuclear envelope barrier leak induced by
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Lilian Kastrup; Hans Oberleithner; Yvonne Ludwig; Claudia Schafer; Victor Shahin
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Article
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2005
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John Wiley and Sons
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English
โ 377 KB
## Abstract Nuclear pore complexes (NPCs) are multiprotein channels that span the nuclear envelope. They strongly limit the efficiency of gene transfection by restriction of nuclear delivery of exogenously applied therapeutic macromolecules. NPC dilation could significantly increase this efficiency