𝔖 Bobbio Scriptorium
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Transient Lambert-Eaton myasthenic syndrome associated with systemic lupus erythematosus

✍ Scribed by Dr. Mark B. Bromberg; James W. Albers; Dr. W. Joseph McCune

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
427 KB
Volume
12
Category
Article
ISSN
0148-639X

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✦ Synopsis

We present a patient who developed the Lambert-Eaton myasthenic syndrome (LEMS) in association with systemic lupus erythematosus (SLE). Severe proximal weakness with electrodiagnostic evidence of LEMS developed over 2 days during an exacerbation of cutaneous manifestations (bullous pemphigoid) associated with SLE. Following an increase in the daily dose of prednisone, there was complete clinical restitution of strength within 2 weeks and a slower resolution of electrodiagnostic abnormalities over 6 months. Marked serologic abnormalities were present at the onset and showed improvement over 6-8 months. LEMS had been infrequently described in association with SLE. The immunologic features of both SLE and LEMS suggest a linkage between the two diseases in this patient. We hypothesize that increased antibodies associated with exacerbation of SLE cross reacted with the neuromuscular junction membrane to produce LEMS.

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