Transient increases of growth fraction during fractionated radiation therapy for cervical carcinoma ki-67 and pc10 immunostaining
✍ Scribed by Kuniyuki Oka; Takashi Nakano; Tanji Hoshi
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 686 KB
- Volume
- 72
- Category
- Article
- ISSN
- 0008-543X
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✦ Synopsis
Background. The Ki-67 and PClO indexes are consistent with the growth and S-phase fractions, respectively.
Methods. Eighty-three biopsy specimens from 18 patients with cervical squamous cell carcinoma were examined before and during fractionated radiation therapy (RT), using an immunohistochemical method.
Results. The 18 patients were divided into two groups according to the Ki-67 index before RT; those with values of less than 42% (Group A; n = 11) and those with values of 42% or more (Group B; n = 7). The Ki-67 index in Group A increased approximately twofold at radiation doses of 5.4-9 Gy compared with values before RT. The Ki-67 index in Group B, which increased slightly at doses of 5.4-9 Gy, decreased by approximately one-fifth at a dose of 27 Gy, compared with the value before RT. The PClO indexes in both groups showed little change to doses of 5.4-9 Gy. The mitotic indexes were less than 1% before RT and decreased to a minimum with doses of 18-27 Gy. There was no correlation between the Ki-67 and PClO indexes before or during RT.
Conclusion. In cancer tissues with a low growth fraction before RT, radiation doses of 5.4-9 Gy produced increases in the numbers of cycling cancer cells in the G1 or G2 phases. This transient increase possibly was attrib-From the Sections of